Process Development /

Protein Structure Research

Protein structure research

In our state-of-art laboratories we are able to perform all needed routine protein analyses throughout all project stages including final product characterization according to all regulatory requirements.

We perform:

  • Protein identification
  • Peptide mapping
  • Amino Acid Composition Analysis
  • Protein sequencing (Maldi-ISD;  ESI-MS/MS)
  • Disulfide linkages analysis
  • Analysis of post-translational modifications (such as oxidation, deamidation)
  • Glycosylation analysis
  • Proteomics
  • Cell metabolites analysis
  • Process- or product-related impurity’s identification
  • Comparability studies of biosimilar
  • Release testing
  • Protein-Protein, antibody-antigen interaction analysis
  • Affinity and binding kinetics determination

State-of-the-art equipment in combination with the up-to-date software enables us to meet highest analytical requirements. Constantly upgradable and improvable instruments:

  • ESI-TOF Mass spectrometer MicrOTOF-Q II Bruker, connected with Waters LC system
  • Maldi-TOF Mass spectrometer Autoflex Speed Bruker
  • Surface Plasmon resonance instrument - Biacore X100
  • Perkin Elmer LS55 Luminescence spectrometer